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However, their clinical translation is limited by potential limitations: 1) impaired tissue repair capacity due to senescent cell clearance, 2) off-target cytotoxicity to nonsenescent cells, and 3) transient inflammatory responses triggered by released cellular contents and inflammatory mediators

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[DOI] [PMC free article] [PubMed] [Google Scholar] 250.Kim J., Moody J.P., Edgerly C.K., Bordiuk O.L., Cormier K., Smith K., Beal M.F., Ferrante R.J